Systematic Review of Randomized Clinical Trials | 2024
A 2024 systematic review evaluated eight randomized clinical trials involving 937 patients treated with BMC for knee osteoarthritis. Patients receiving BMC demonstrated improvement in pain and function from baseline. Some
comparisons favored BMC over hyaluronic acid, although differences between treatments did not always reach
thresholds considered clinically meaningful.
Why it Matters
This review combines evidence from multiple randomized clinical trials rather than relying on a single study.
*Orthobiologic therapies remain an evolving area of medicine. The quality and quantity of research vary depending on the treatment, diagnosis, and application. Individual outcomes vary. No orthobiologic treatment can guarantee elimination of pain, regeneration of cartilage or other tissue, prevention of future surgery, return to a particular sport or activity, or a specific degree or duration of improvement.
The information presented on this page is intended for educational purposes and should not be interpreted as a guarantee of treatment effectiveness or as a substitute for individualized medical evaluation.*
